When Medusa officially joined the Fantastic Four in 1973, the lady with the living locks was right there to help out Reed whenever he became distraught about Sue. Sure, when helping Reed Medusa had a tendency to "play rough" (to use the Sandman's phrase)...but she sometimes followed that up with a dinner invitation, so all was forgiven.
And although nothing ever happened romance-wise, maybe just maybe deep-down Reed felt the same way--he sure didn't seem to like the sight of Medusa cozying up with Johnny, did he?
Well, I suppose Mr. Richards was a wee too distracted to properly appreciate Medusa's abundant charms. Perhaps Ben, with his down to earth manner and gruff charm--"Do me a favor, Red--don't do me any favors!"--would have been a better match for her, but he was dating Alicia; plus Thundra had the hots for him, so his dance card was full...
...but in Giant-Size Fantastic Four #2, away from the heat of the battle, Medusa's preening and Ben's appreciative. Can't you just feel their chemistry here?
Now onto Johnny. In the FF lettercols, Marvel queried the readers about the possibility of a Medusa-Johnny romance (never mind that in every other issue all Johnny did was bend Medusa's ear about her sister, Crystal). In response some readers said yes, others vetoed the idea. Then Marvel said that they'd leave it up to the next creative team to decide, and then--poof!--Medusa finished her tour of duty with the FF and hightailed it back to the Inhumans and her ever-lovin' Black Bolt.
So, no romance ever blossomed between Medusa and Johnny. But no sooner does Medusa leave the FF in #159, then what does Johnny do but fall for a stunner who bears a resemblance to a certain Marvel-ous redhead (and not just MJ!)...well, see for yourself, Tiger!