Recently, commenter Anonymous opined that Reed should have hooked up with Medusa
back when Sue left him, and I agree! Regrettably, that never came to pass--that would have been one hell of a storyline--but as a consolation, here's a rollickin' Rich Buckler panel from Fantastic Four #157 with Medusa doing her best Sue imitation.
I'd say the marvelous Madame M. looks pretty good alongside Mr. Fantastic, don't you think? ;)